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Patents

Oct 14, 202615 min read

title:: Patents

people:: Razvan Ionasec, Dorin Comaniciu, Bogdan Georgescu, Yefeng Zheng, Ingmar Voigt, Tommaso Mansi, Puneet Sharma, Viorel Mihalef, Sasa Grbic, Matthias John, Helene Houle, Nassir Navab, Jan Boese, Dime Vitanovski, Lucian Itu, Kristof Ralovich

organization:: Siemens Corporate Research, Siemens Healthineers, Siemens AG

domain:: Medical Imaging, Machine Learning, Computational Modeling, Biomechanics, Cardiology, Clinical Decision Support

link:: https://patents.google.com/?inventor=Razvan+Ionasec

patents:: 60 publications · 43 granted · 56 distinct inventions — as of 14 October 2026

patents

Figure 1 from four of the patents — US8224640B2 (patient-specific 4D heart model and FSI simulation), US10719986B2 (virtual percutaneous valve implantation), US9245091B2 (physically-constrained cardiac modelling), US11056228B2 (ontology-driven evaluation of examination results). Drawings are public records from the published patent documents.

Summary

Most of the research described under Publications was filed as well as published. Sixty patent publications name me as an inventor — 43 granted and 17 published applications, covering 56 distinct inventions, filed with Siemens between 2008 and 2019.

Each patent has its own page — the list below links to all 60, and every entry carries the full abstract, the figure from the published document, legal status, assignee and co-inventors.

The portfolio tracks the same arc as the papers, and then continues past them:

  • Patient-specific cardiac and valve modelling — automatic quantification of aortic valve function, dynamic pulmonary trunk modelling, complete multi-component heart and aorta models, physically-constrained modelling, regression-based 4D mitral valve segmentation, mitral valve detection on transthoracic echo.
  • Simulation and haemodynamics — computational modelling of the aorta and heart with fluid-structure-interaction simulation and estimated aortic wall material properties, patient-specific assessment of virtual stent implantation, hemodynamic assessment of aortic coarctation, estimation of a mechanical property of anatomy from scan data.
  • Transcatheter intervention planning — virtual percutaneous valve implantation against a library of implant models, TAVI intervention planning, advanced TAVI planning, aortic valve calcification evaluation, valve treatment simulation, virtual stent implantation.
  • Multi-modal image fusion and interventional guidance — physiological image registration and fusion, model-based fusion of CT with non-contrasted C-arm CT, registration of ultrasound and physiological models to X-ray fluoroscopy, intracardiac echo volume stitching, pericardium-based model fusion, C-arm angulation planning, dose-reduced X-ray sequences.
  • AI clinical decision support and imaging workflow — the later Siemens Healthineers period: ontology-driven evaluation of examination results combining a vision model with NLP over the report, computer-based diagnostic systems, automated evaluation of image data sets, imaging protocol selection, image-reconstruction optimisation, deep-learning malignancy assessment of pulmonary nodules, and flexible use of a clinical decision support system. Five of these name me as sole inventor.
  • One outlier, and the earliest filing of all — DE102008020381A1, filed April 2008 with Rupert Maier — a data collecting system for industrial plant. Its own description names power plants, production plants, factories and energy generation and distribution. No medicine in it at all, and it predates the first cardiac filing by six months.

The work was recognised with the Thomas Edison Patent Award for System for Planning Heart Valve Surgery (Princeton, November 2015).

Data Points

  • 60 patent publications name me as inventor — 46 US, 11 EP, 2 DE, 1 JP.
  • 43 granted (39 US B2, 4 EP B1) and 17 published applications.
  • 56 distinct inventions — four appear twice, as a continuation or a second jurisdiction.
  • Status today — 38 active, 5 granted-then-lapsed, 6 granted elsewhere, 4 abandoned, 6 withdrawn, 1 ceased.
  • Filing window 2008-04-23 to 2019-10-30. First grant 2011, most recent grant 2023.
  • All assigned to Siemens — Siemens AG, Siemens Corporation, Siemens Healthcare GmbH or Siemens Medical Solutions USA.
  • Five sole-inventor filings — US11056228B2, US11170499B2, US10540480B2, EP3654251B1, EP3667674A1.
  • Most frequent co-inventors — Dorin Comaniciu, Bogdan Georgescu, Yefeng Zheng, Ingmar Voigt, Tommaso Mansi, Puneet Sharma, Matthias John.

Compiled 14 October 2026 from a Google Patents inventor search across the name variants Razvan Ioan Ionasec, Razvan Ionasec and Razvan I. Ionasec, then verified document by document against each patent’s own inventor metadata.

Four records the search returned are excluded, because the documents do not name me — they are Philips and FujiFilm filings that merely cite this work (DE102011079561B4, EP2561481B1, JP2012245222A, US9224188B2). Every entry below was individually confirmed.

Counting convention — a publication is one patent document; an invention groups the documents that share a title across continuations and jurisdictions. “Granted” is read from the kind code (B1/B2), not from the status line.

Granted patents (43)

  1. DETERMINATION OF THE PROCESSING OF A SEQUENCE FOR PROCESSING AN IMAGE EP3654251B1 · filed 2018-11-13 · granted 2025-12-31 · Active Assignee Siemens Healthineers AG. Co-inventors — sole inventor.

  2. Flexible use of a clinical decision support system US11734599B2 · filed 2018-03-28 · granted 2023-08-22 · Active Assignee Siemens Healthcare GmbH. Co-inventors — Peng Hao, Philipp HOELZER.

  3. Processing a medical image EP3657391B1 · filed 2018-11-21 · granted 2023-07-26 · Active Assignee Siemens Healthcare GmbH. Co-inventors — Jonathan Sperl, Rainer Kärgel, Guillaume CHABIN, Sasa Grbic, Dorin Comaniciu.

  4. Method for analysing a medical imaging data set, system for analysing a medical imaging data set, computer program product and a computer-readable medium EP3467770B1 · filed 2017-10-05 · granted 2022-11-23 · Active Assignee Siemens Healthcare GmbH. Co-inventors — Andre Hartung.

  5. Method for setting a medical imaging protocol, system for setting a medical instrument, computer program and computer-readable medium US11393576B2 · filed 2018-09-26 · granted 2022-07-19 · Active Assignee Siemens Healthcare GmbH. Co-inventors — Philipp HOELZER.

  6. Method and device for the automated evaluation of at least one image data record recorded with a medical image recording device, computer program and electronically readable data carrier US11170499B2 · filed 2018-11-20 · granted 2021-11-09 · Active Assignee Siemens Healthcare GmbH. Co-inventors — sole inventor.

  7. Method and system for evaluating medical examination results of a patient, computer program and electronically readable storage medium US11056228B2 · filed 2019-01-09 · granted 2021-07-06 · Active Assignee Siemens Healthcare GmbH. Co-inventors — sole inventor.

  8. Computer-based diagnostic system US10910094B2 · filed 2018-11-20 · granted 2021-02-02 · Active Assignee Siemens Healthcare GmbH. Co-inventors — Andre Hartung.

  9. Personalized creation from medical imaging US10751943B2 · filed 2015-08-24 · granted 2020-08-25 · Active Assignee Siemens Healthcare GmbH. Co-inventors — Sasa Grbic, Michael Suehling, Tommaso Mansi, Ingmar Voigt, Bogdan Georgescu, Helene C. Houle, Dorin Comaniciu, Charles Henri Florin, Philipp HOELZER.

  10. Method and system for virtual percutaneous valve implantation US10719986B2 · filed 2010-12-22 · granted 2020-07-21 · Active Assignee Siemens Healthcare GmbH. Co-inventors — Dominik Zaeuner, Bogdan Georgescu, Yefeng Zheng, Dorin Comaniciu, Ingmar Voigt, Jan Boese.

  11. Method and data processing unit for optimizing an image reconstruction algorithm US10614597B2 · filed 2017-07-26 · granted 2020-04-07 · Active Assignee Siemens Healthcare GmbH. Co-inventors — Philipp HOELZER.

  12. Medical imaging system US10540480B2 · filed 2017-08-22 · granted 2020-01-21 · Active Assignee Siemens Healthcare GmbH. Co-inventors — sole inventor.

  13. Landmark detection with spatial and temporal constraints in medical imaging EP3152736B1 · filed 2015-06-08 · granted 2020-01-08 · Active Assignee Siemens Healthcare GmbH. Co-inventors — Mihai SCUTARU, Ingmar Voigt, Tommaso Mansi, Helene C. Houle, Anand Vinod TATPATI, Dorin Comaniciu, Bogdan Georgescu, Noha Youssry El-Zehiry.

  14. Method and computing unit for generating a manufacturing model US10299863B2 · filed 2016-06-10 · granted 2019-05-28 · Active Assignee Siemens Healthcare GmbH. Co-inventors — Sasa Grbic, Philipp HOELZER, Michael Suehling.

  15. Method and system for advanced transcatheter aortic valve implantation planning US9931790B2 · filed 2015-04-16 · granted 2018-04-03 · Active Assignee Siemens Healthcare GmbH. Co-inventors — Sasa Grbic, Tommaso Mansi, Ingmar Voigt, Dominik Neumann, Julian Krebs, Chris Schwemmer, Max Schoebinger, Helene C. Houle, Dorin Comaniciu, Joel Mancina.

  16. Method and system for model-based fusion of multi-modal volumetric images US9824302B2 · filed 2012-03-06 · granted 2017-11-21 · Active Assignee Siemens Healthcare GmbH. Co-inventors — Sasa Grbic, Yang Wang, Bogdan Georgescu, Tommaso Mansi, Dorin Comaniciu, Yefeng Zheng, Shaohua Kevin Zhou, Matthias John, Jan Boese.

  17. Method and system for aortic valve calcification evaluation US9730609B2 · filed 2012-12-13 · granted 2017-08-15 · Active Assignee Siemens Healthcare GmbH. Co-inventors — Sasa Grbic, Fernando Vega-Higuera, Dominik BERNHARDT, Dorin Comaniciu.

  18. Method and system for registration of ultrasound and physiological models to X-ray fluoroscopic images US9687204B2 · filed 2012-05-18 · granted 2017-06-27 · Active Assignee Siemens Healthcare GmbH. Co-inventors — Peter Mountney, Markus Kaiser, Ingmar Voigt, Matthias John, Jan Boese, Dorin Comaniciu.

  19. Image fusion for interventional guidance US9681856B2 · filed 2015-12-15 · granted 2017-06-20 · Active Assignee Siemens AG. Co-inventors — Peter Mountney, Sasa Grbic, Matthias John, Dorin Comaniciu.

  20. Estimation of a mechanical property of anatomy from medical scan data US9585632B2 · filed 2014-04-23 · granted 2017-03-07 · Active Assignee —. Co-inventors — Jingjing Kanik, Puneet Sharma, Tommaso Mansi, Ali Kamen, Dorin Comaniciu, James S. Duncan, Yale University, Siemens Medical Solutions USA Inc.

  21. Method and system for physiological image registration and fusion US9547902B2 · filed 2009-09-18 · granted 2017-01-17 · Active Assignee Siemens Healthcare GmbH. Co-inventors — Bogdan Georgescu, Yefeng Zheng, Dorin Comaniciu.

  22. Method and system for generating a personalized anatomical heart model US9405996B2 · filed 2009-09-18 · granted 2016-08-02 · Expired - Fee Related Assignee Siemens AG. Co-inventors — Bogdan Georgescu, Yefeng Zheng, Dorin Comaniciu.

  23. Method and system for model-based fusion of computed tomography and non-contrasted C-arm computed tomography US9292917B2 · filed 2012-11-21 · granted 2016-03-22 · Active Assignee Siemens AG. Co-inventors — Sasa Grbic, Matthias John, Jan Boese, Christian Gesell, Dorin Comaniciu.

  24. Method and system for obtaining a sequence of x-ray images using a reduced dose of ionizing radiation US9259200B2 · filed 2012-10-18 · granted 2016-02-16 · Active Assignee Siemens AG. Co-inventors — Peter Mountney, Andreas Maier, Jan Boese, Dorin Comaniciu.

  25. Image fusion for interventional guidance US9247880B2 · filed 2013-02-25 · granted 2016-02-02 · Active Assignee Siemens AG. Co-inventors — Peter Mountney, Sasa Grbic, Matthias John, Jan Boese, Dorin Comaniciu.

  26. Physically-constrained modeling of a heart in medical imaging US9245091B2 · filed 2012-03-09 · granted 2016-01-26 · Active Assignee Siemens Corporation. Co-inventors — Ingmar Voigt, Bogdan Georgescu, Tommaso Mansi, Dorin Comaniciu, Helene C. Houle, Etienne Assoumou Mengue, Siemens Medical Solutions USA Inc.

  27. Method and system for regression-based 4D mitral valve segmentation from 2D+t magnetic resonance imaging slices US9196049B2 · filed 2012-03-09 · granted 2015-11-24 · Active Assignee Siemens AG. Co-inventors — Dime Vitanovski, Alexey Tsymbal, Gareth Funka-Lea, Dorin Comaniciu, Andreas Greiser, Edgar Mueller.

  28. Model-based positioning for intracardiac echocardiography volume stitching US9179890B2 · filed 2012-07-11 · granted 2015-11-10 · Active Assignee Siemens AG. Co-inventors — Sasa Grbic, Estelle Camus, Dorin Comaniciu, Siemens Medical Solutions USA Inc.

  29. Method and system for model based fusion on pre-operative computed tomography and intra-operative fluoroscopy using transesophageal echocardiography US9155470B2 · filed 2013-01-15 · granted 2015-10-13 · Active Assignee Siemens AG. Co-inventors — Sasa Grbic, Peter Mountney, Matthias John, Jan Boese, Dorin Comaniciu.

  30. Method and system for hemodynamic assessment of aortic coarctation from medical image data US9135699B2 · filed 2013-03-14 · granted 2015-09-15 · Active Assignee Siemens AG. Co-inventors — Kristof Ralovich, Lucian Mihai Itu, Viorel Mihalef, Puneet Sharma, Dime Vitanovski, Waldemar Krawtschuk, Dorin Comaniciu.

  31. Mitral valve detection for transthoracic echocardiography US9033887B2 · filed 2013-05-30 · granted 2015-05-19 · Active Assignee Siemens Corporation. Co-inventors — Dime Vitanovski, Yang Wang, Bogdan Georgescu, Ingmar Voigt, Saurabh Datta, Dorin Comaniciu, Siemens Medical Solutions USA Inc.

  32. Method and system for patient-specific hemodynamic assessment of virtual stent implantation US8983809B2 · filed 2011-12-06 · granted 2015-03-17 · Active Assignee Siemens AG. Co-inventors — Puneet Sharma, Viorel Mihalef, Bogdan Georgescu, Dorin Comaniciu.

  33. Method and system for intervention planning for transcatheter aortic valve implantation from 3D computed tomography data US8934693B2 · filed 2012-11-21 · granted 2015-01-13 · Active Assignee Siemens AG. Co-inventors — Sasa Grbic, Fernando Vega-Higuera, Dominik BERNHARDT, Bogdan Georgescu, Dorin Comaniciu.

  34. Valve treatment simulation from medical diagnostic imaging data US8920322B2 · filed 2012-03-05 · granted 2014-12-30 · Active Assignee Siemens AG. Co-inventors — Tommaso Mansi, Ingmar Voigt, Bogdan Georgescu, Dorin Comaniciu, Etienne Assoumou Mengue.

  35. Method and system for medical decision support using organ models and learning based discriminative distance functions US8812431B2 · filed 2011-01-28 · granted 2014-08-19 · Active Assignee Siemens AG. Co-inventors — Ingmar Voigt, Dime Vitanovski, Alexey Tsymbal, Bogdan Georgescu, Shaohua Kevin Zhou, Martin Huber, Dorin Comaniciu.

  36. Valve assessment from medical diagnostic imaging data US8771189B2 · filed 2010-02-08 · granted 2014-07-08 · Active Assignee Siemens Corporation. Co-inventors — Ingmar Voigt, Yang Wang, Bogdan Georgescu, Helene C. Houle, Dorin Comaniciu, Fernando Vega-Higuera, Siemens Medical Solutions USA Inc.

  37. Method and system for comprehensive patient-specific modeling of the heart US8682626B2 · filed 2011-04-20 · granted 2014-03-25 · Active Assignee Siemens AG. Co-inventors — Ingmar Voigt, Viorel Mihalef, Sasa Grbic, Dime Vitanovski, Yang Wang, Yefeng Zheng, Bogdan Georgescu, Dorin Comaniciu, Puneet Sharma, Tommaso Mansi.

  38. Method and system for dynamic pulmonary trunk modeling and intervention planning US8538109B2 · filed 2010-03-16 · granted 2013-09-17 · Expired - Fee Related Assignee Siemens AG. Co-inventors — Dime Vitanovski, Bogdan Georgescu, Martin Huber, Dorin Comaniciu.

  39. Method and system for intraoperative guidance using physiological image fusion US8532352B2 · filed 2011-10-06 · granted 2013-09-10 · Expired - Fee Related Assignee Siemens AG. Co-inventors — Ingmar Voigt, Bogdan Georgescu, Yefeng Zheng, Jan Boese, Klaus Klingenbeck, Dorin Comaniciu.

  40. Method and system for multi-component heart and aorta modeling for decision support in cardiac disease US8527251B2 · filed 2010-04-30 · granted 2013-09-03 · Expired - Fee Related Assignee Siemens AG. Co-inventors — Puneet Sharma, Bogdan Georgescu, Andrey Torzhkov, Fabian Moerchen, Gayle M. Wittenberg, Dmitriy Fradkin, Dorin Comaniciu.

  41. Method and system for computational modeling of the aorta and heart US8224640B2 · filed 2010-06-29 · granted 2012-07-17 · Active Assignee Siemens AG. Co-inventors — Puneet Sharma, Bogdan Georgescu, Dorin Comaniciu.

  42. Dynamic pulmonary trunk modeling in computed tomography and magnetic resonance imaging based on the detection of bounding boxes, anatomical landmarks, and ribs of a pulmonary artery US8218845B2 · filed 2008-12-01 · granted 2012-07-10 · Expired - Fee Related Assignee Siemens AG. Co-inventors — Michael Lynch, Bogdan Georgescu, Dorin Comaniciu, Dime Vitanovski.

  43. Method and system for automatic quantification of aortic valve function from 4D computed tomography data using a physiological model US8009887B2 · filed 2008-10-17 · granted 2011-08-30 · Active Assignee Siemens Corporation. Co-inventors — Bogdan Georgescu, Helene C. Houle, Sebastian Vogt, Michael Scheuering, Estelle Camus, Dorin Comaniciu.

Published applications (17)

Filed and published, but not granted — withdrawn, abandoned, or still in examination.

  1. Determining malignancy of pulmonary nodules using deep learning EP3648057A1 · filed 2019-10-30 · published 2020-05-06 · Granted Assignee Siemens Healthcare GmbH. Co-inventors — Sasa Grbic, Dorin Comaniciu, Bogdan Georgescu, Siqi LIU.

  2. Method and system for evaluating images of different patients, computer program and electronically readable storage medium EP3667674A1 · filed 2018-12-12 · published 2020-06-17 · Withdrawn Assignee Siemens Healthcare GmbH. Co-inventors — sole inventor.

  3. Method for controlling an evaluation device for medical images of patient, evaluation device, computer program and electronically readable storage medium US20190164643A1 · filed 2018-11-27 · published 2019-05-30 · Granted Assignee Siemens Healthcare GmbH. Co-inventors — Bjoern Heismann.

  4. Processing image data for training an image processing system EP3657394A1 · filed 2018-11-21 · published 2020-05-27 · Withdrawn Assignee Siemens Healthcare GmbH. Co-inventors — Sasa Grbic, Jonathan Sperl.

  5. Computer-based diagnostic system US20190164642A1 · filed 2018-11-20 · published 2019-05-30 · Granted Assignee Siemens Healthcare GmbH. Co-inventors — Andre Hartung.

  6. Method and system for generating estimation data for potential injury states US20180330823A1 · filed 2018-05-09 · published 2018-11-15 · Abandoned Assignee Siemens Healthcare GmbH. Co-inventors — Philipp HOELZER, Sebastian Schmidt, Amitkumar Bhupendrakumar Shah.

  7. Optimization of clinical decision making US20180315505A1 · filed 2018-04-03 · published 2018-11-01 · Abandoned Assignee Siemens Healthcare GmbH. Co-inventors — Lucian Mihai Itu, Puneet Sharma, Dorin Comaniciu.

  8. Automated processing of patient data for health care EP3454341A1 · filed 2017-09-12 · published 2019-03-13 · Withdrawn Assignee Siemens Healthcare GmbH. Co-inventors — Sebastian Schmidt, Amitkumar Bhupendrakumar Shah.

  9. Automated detection and processing of patient data for health care EP3454342A1 · filed 2017-09-12 · published 2019-03-13 · Withdrawn Assignee Siemens Healthcare GmbH. Co-inventors — Sebastian Schmidt, Amitkumar Bhupendrakumar Shah.

  10. Macroscopic monitoring of the health status of a collective EP3384828A1 · filed 2017-04-04 · published 2018-10-10 · Withdrawn Assignee Siemens Healthcare GmbH. Co-inventors — Sebastian Schmidt, Amitkumar Bhupendrakumar Shah.

  11. Method and data processing unit for determining an acquisition data processing algorithm DE102016215105A1 · filed 2016-08-12 · published 2017-09-07 · Withdrawn Assignee Siemens Healthcare GmbH. Co-inventors — Philipp Hölzer.

  12. Patient position control for computed tomography during minimally invasive intervention US20160242710A1 · filed 2015-02-23 · published 2016-08-25 · Abandoned Assignee Siemens AG. Co-inventors — Sasa Grbic, Stefan Reichelt.

  13. Method and apparatus for image fusion based planning of c-arm angulation for structural heart disease EP2956065A1 · filed 2014-02-12 · published 2015-12-23 · Granted Assignee Siemens Corporation. Co-inventors — Matthias John, Murrill Michael SZUCS, Alois Noettling, Siemens Medical Solutions USA Inc.

  14. Method and Apparatus for Image Fusion Based Planning of C-Arm Angulation for Structural Heart Disease US20150223773A1 · filed 2014-02-11 · published 2015-08-13 · Abandoned Assignee Siemens AG. Co-inventors — Matthias John, Murril Michael Szucs, Alois Noettling, Siemens Medical Solutions USA Inc.

  15. Method and System for Pericardium Based Model Fusion of Pre-operative and Intra-operative Image Data for Cardiac Interventions US20130294667A1 · filed 2013-02-13 · published 2013-11-07 · Granted Assignee Siemens Corporation. Co-inventors — Yefeng Zheng, Sasa Grbic, Matthias John, Jan Boese, Dorin Comaniciu.

  16. Method and system for comprehensive patient-specific modeling of the heart JP2012024582A · filed 2011-07-21 · published 2012-02-09 · Granted Assignee Siemens Corporation. Co-inventors — イオアン イオナセク ラズヴァン, Ingmar Voigt, フォイクト イングマー, Viorel Mihalef, ミハレフ ヴィオレル, Sasa Grbic, グルビチ ササ, Dime Vitanovski, ヴィタノフスキ ディメ, Yan Wang, ワン ヤン, Yefeng Zheng, ジェン イェフェン, Bogdan Georgescu, ゲオルゲスク ボグダン, Dorin Comaniciu, コマニチ ドリン, Tommaso Mansi, マンシ トマソ, Puneet Sharma, シャルマ プネート.

  17. Data collecting system for e.g. industrial system, has interfaces transmitting process samples to central database, and processing mechanism generating knowledge about industrial systems by using samples and optimization potentials DE102008020381A1 · filed 2008-04-23 · published 2009-10-29 · Ceased Assignee Siemens Corporation. Co-inventors — Rupert Maier.

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